We supply machinery and equipment, including wet granulation machines used in pharmaceutical manufacturing.

A Wet Granulation Machine is an essential piece of equipment widely used in pharmaceutical, nutraceutical, chemical, and food industries. The machine is designed to mix powder materials and convert them into uniform granules through a controlled wet granulation process.

This technology is based on the principle of Wet Granulation, which is one of the most widely used methods in modern pharmaceutical manufacturing for producing tablets and capsules with consistent quality and improved flowability.

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Applications of Wet Granulation Machine

The wet granulation machine is commonly used in various industries, including:

• Pharmaceutical industry – tablet and capsule production

• Nutraceutical manufacturing – vitamins and supplements

• Chemical industry – granulation of powder chemicals

• Food industry – processing powdered ingredients

The equipment enables efficient physical mixing of multiple materials. After the mixing stage, materials can undergo a granulation process through atomized liquid addition, high-speed stirring, and high-speed shearing, allowing precise control of processing parameters such as rotation speed and processing time.

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Working Principle Wet Granulation

The raw materials are charged into the granulation bowl through a vacuum feeding system or manual loading. A binder solution is then introduced into the mixing chamber through a spraying system, allowing the powder particles to become properly wetted and prepared for granulation.

As the impeller rotates at high speed, it generates a strong vortex flow inside the bowl. This vortex motion promotes intensive mixing and kneading of the powder mass, enabling the particles to collide, agglomerate, and gradually form moist granules.

At the intersection zone of the material flow, a side-mounted high-speed chopper breaks and cuts the tumbling wet mass into smaller granules. This process ensures that the granules produced have uniform particle size, consistent structure, and good flow properties, making them suitable for subsequent processing steps such as drying, tablet compression, or capsule filling.

This granulation process is widely used in pharmaceutical manufacturing and follows the principle of Wet Granulation to achieve stable and high-quality granule formation.

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Key Features of the Wet Granulation Machine

Flexible Batch Requirements

The equipment supports interchangeable bowls of different volumes, allowing one machine to handle multiple experimental batch sizes.

The bowl design follows proportional scale-up principles, making it suitable for both laboratory research and industrial production.

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Quick Bowl Replacement

The integrated granulating bowl design allows for fast bowl replacement without removing the impeller, significantly reducing downtime and improving production efficiency.

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Anti-Clogging Impeller Design (Patent No: ZL202020487118.2)

The impeller features a “reverse-push” blade design at the center bottom, effectively preventing material accumulation around the central shaft.

This innovative structure improves mixing efficiency and ensures stable granulation performance.

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Anti-Clogging Chopper Design (Patent No: ZL 202020100976.7)

The chopper installed near the bowl wall includes a reverse-push blade design, which prevents material buildup around the cutting tips and ensures smooth granule formation.

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Ultra-Low Clearance Design

The gap between the bowl bottom and the impeller is extremely small (0.3–1 mm).

This design effectively eliminates material stagnation at the bottom, ensuring complete mixing and granulation.

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Granulation End-Point Determination

Depending on production requirements, the system can determine the granulation end point using different parameters such as:

• Torque monitoring

• Power or work consumption

• Electrical current

These monitoring methods ensure accurate and consistent granulation quality.

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Air Intake Protection System

Both the impeller shaft and chopper shaft are equipped with positive pressure air-intake protection systems.

This design prevents powder from entering the shaft structure, protecting internal components and extending equipment lifespan.

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Customized Configuration Options

The machine can be configured according to specific production requirements, including:

• Z-shaped impellers

• Eccentric impellers

• Air-assisted spray systems

• Airless spray systems

These flexible configurations allow the equipment to adapt to different process needs.

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Full GMP Compliance

The wet granulation machine is fully compliant with the requirements of Good Manufacturing Practice (GMP).

Key features include:

• Three-level password authorization system

• PLC-based automatic process control

• Online data storage for all process parameters

• USB data export capability for documentation and traceability

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Experimental model specifications and main technical parameters:

Production specifications and main technical parameters:

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Our Services in Southeast Asia

Our equipment supply and installation services are available in the following countries:

• Vietnam

• Thailand

• Malaysia

• Singapore

• Indonesia

• Philippines

• Cambodia

• Laos

• Myanmar

• Brunei

• Timor-Leste

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Contact

The Wet Granulation Machine plays a crucial role in modern pharmaceutical manufacturing by ensuring efficient mixing, precise binder addition, and uniform granule formation. With advanced design features, GMP compliance, and flexible configurations, the equipment provides a reliable solution for both laboratory research and large-scale industrial production.

Tin Nghi Dac Pharmaceutical Equipment Co., Ltd.

Tax Code: 3703422032
Office phone: (+84)28 66719989
Mobile: (+84)329 280 289
Email: info@xinyite.com.vn
Address: 49C D11 Street, Group 18, Quarter 4, An Phu Ward, Ho Chi Minh City, Vietnam.