Applications: Designed for pellet production using the extrusion-spheronization method. It is an ideal system for preparing blank pellets and drug-loaded cores in pharmaceutical, food, and chemical industries. It also supports drying, drug layering, and coating of the produced pellets.
Operating Principle: Powders and excipients are uniformly mixed with a wetting agent to form a wet mass. The material is fed by a screw and pushed by a paddle feeder into the extrusion chamber. Under radial extrusion pressure, it is forced through a cylindrical perforated screen to form dense extrudates. These extrudates enter the spheronizer bowl, where the rotation of the friction plate—driven by combined forces of shear, centrifugal motion, and friction—transforms them into high-quality spherical granules.
Key Features:
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Multi-functional (Lab Scale): A single machine can perform five distinct processes: Extrusion, Spheronization, Granulation, Drying, and Drug Layering/Coating.
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Cooling System: A water circulation system cools both the extrusion screw and the barrel simultaneously, reducing material temperature and preventing thermal degradation during high-pressure extrusion.
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Multiple Die Plate Options: Various screen sizes and thicknesses are available to produce micro-pellets from 0.2mm to 3.0mm.
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Square-Profile Friction Plate: The friction plate features a square-groove design for more uniform shearing, shorter spheronization time, higher yield, and increased efficiency.
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Side-Spray Coating (Lab Model): By swapping the friction plate, the system can perform side-spray coating, offering higher efficiency than traditional fluidized beds.
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Automated Production: Enables fully integrated automated production, including feeding, extrusion, weighing, spheronization, and discharging.
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Customization: Options for single-screw or paddle-style feeders, online liquid spray systems for spheronization, hot-melt coating systems, etc.
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GMP Compliance: Features three-level password authorization. All process parameters are PLC-controlled, with automatic online data storage and USB export capability.
Laboratory Model Specifications and Main Technical Parameters:
| Model Name | E-25 | Mini S | Mini 250 | Mini 250-C |
|---|---|---|---|---|
| Pelletizing Capacity (kg/h) | 0.1-0.3 | 60mm (5-20g/batch)
80mm (20-50g/batch) 120mm (50-100g/batch) |
1-3 | 1-3 |
| Coating Capacity (kg/batch) | — | — | — | 0.3-1.5 |
| Available Pellet Diameter (mm) | 0.2-3.0 | 0.2-3.0 | 0.2-3.0 | 0.2-3.0 |
| Extrusion Speed (rpm) | Digital Display – Adj. | — | 3-50 | 3-50 |
| Spheronization Speed (rpm) | — | Digital Display – Adj. | 100-2000 | 100-2000 |
| Extrusion Screw Diameter (mm) | 25 | — | 50 | 50 |
| Turntable Diameter (mm) | — | 60/80/120 | 250 | 250 |
| Coating Temperature (℃) | — | — | — | 15-90 |
| Power Supply | 220V/50Hz 1P 3W | 220V/50Hz 1P 3W | 220V/50Hz 1P 3W | 380V/50Hz 3P 5W |
| Air Source Pressure (Mpa) | — | — | 0.4 | 0.4 |
| Extrusion Motor (kW) | 0.12 (30:1) | — | 0.75 | 0.75 |
| Spheronization Motor (kW) | — | 0.25 | 0.75 | 0.75 |
| Atomization Motor (kW) | — | — | — | 0.37 |
| Exchangeable Head Motor (kW) | — | — | 0/0.75 | 0/0.75 |
| Inlet Fan (kW) | — | — | — | 0.75 |
| Exhaust Fan (kW) | — | — | — | 0.75 |
| Electric Heating Power (kW) | — | — | — | 3 |
| Total Power (kW) | 0.12 | 0.25 | 1.5/2.25 | 6.37/7.12 |
| Overall Dimensions (mm) | 400×180×300 | 260×270×450 | 1550×750×1350 | 1950×850×1750 |
| Machine Weight (kg) | 16 | 15 | 330 | 550 |
Note: Mini 250-C features extrusion, spheronization, and coating functions; centrifugal granulation can be added.
Production Model Specifications and Main Technical Parameters:
| Model Name | LTAES100-380 | LTAES100/150-500 | LTAES100/150/200-700 | TAES100/150/200-1000 |
|---|---|---|---|---|
| Capacity (kg/h) | 10-30 | 20-50 | 30-70 | 50-100 |
| Pellet Diameter (mm) | 0.2-3.0 and above 3.0 | |||
| Extrusion Speed (rpm) | 3-50 | 3-50 | 3-50 | 3-50 |
| Spheronization Speed (rpm) | 100-1500 | 100-1000 | 100-750 | 100-500 |
| Extrusion Screw Diameter (mm) | 100 | 100/150 | 100/150/200 | 100/150/200 (Single/Double) |
| Turntable Diameter (mm) | 380 | 500 | 700 | 1000 |
| Power Supply | 380V/50Hz 3P 5W | |||
| Air Source Pressure (Mpa) | 0.6 | 0.6 | 0.6 | 0.6 |
| Extrusion Motor (kW) | 2.2 | 2.2/3.7 | 2.2/3.7/7.5 | 2.2/3.7/7.5 |
| Spheronization Motor (kW) | 2.2 | 3.7 | 5.5 | 7.5 |
| Inlet Fan (kW) | 0.75 | 0.75 | 1.5 | 2.2 |
| Total Power (kW) | 5.15 | 6.65/8.15 | 9.2/10.7/14.5 | 15.4/16.9/20.7 |
| Overall Dimensions (mm) | 1650×800×1700 | 1900×800×1850 | 2800×1200×2000 | 2500×1100×2250 |
| Machine Weight (kg) | 630 | 900 | 1700 | 2600 |
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