Micronization Hydration Crystallizer

Applications

During the formulation process, technical limitations often lead to varying degrees of amorphous states within the crystals. These amorphous phases primarily adsorb onto the crystal surface, altering its surface properties. This significantly impacts subsequent processing stages and compromises the long-term stability of the drug.

Operating Principle

The Micro-powder Hydration Crystallizer operates under strictly controlled temperature and humidity conditions. By introducing a dispersed airflow, the micro-powder enters the reaction vessel and adsorbs water molecules that enrich its surface. This process facilitates the gradual transformation from an amorphous state to a crystalline state while ensuring that the particle size remains unchanged throughout the transition.

Key Features

1. Nested Vessel Design: Features a nested small-scale vessel and a primary production vessel, meeting the requirements for both small-batch laboratory R&D and large-scale commercial production.

2. Tilting Vessel Body: The vessel is designed to flip/tilt, allowing for convenient material feeding and discharging.

3. Advanced Climate Control System: Equipped with a multi-point temperature and humidity regulation system to monitor and adjust internal vessel conditions in real-time.

4. Intelligent Management & Control: * Secured by three-level password authorization.

   • All process parameters are automatically controlled via PLC.

   • All production data is automatically recorded online and can be exported via USB for compliance and analysis.