Hot Melt Extrusion Granulator

APPLICATIONS: This equipment is a proprietary one-step solid dispersion granulator developed by our company for pharmaceutical formulations. It enables one-step granulation for various types of solid dispersions, including taste-masking, solubility enhancement, and targeted release, and can also directly produce sustained/controlled-release granules.

PRINCIPLE: Raw materials and excipients are fed into the hopper via a quantitative feeding device and then uniformly transported by twin screws. The screws are heated in stages with a gradual temperature increase, causing the materials to melt and achieve mutual solubility in the middle section. After staged cooling, the material is extruded through a die plate to form dense, solid strands. These strands are then processed by a conveying and shearing device to obtain the target particle size.

FEATURES:

1. Feeding System: Vibratory or twin-screw feeders are available to meet the feeding requirements of materials with different properties.

2. Heating Method: Designed with segmented electric heating for both upper and lower barrels simultaneously, ensuring uniform heat distribution.

3. Multi-stage Precision Temperature Control (Accuracy ±0.5°C): Utilizes a precise feedback system to ensure stable, interference-free temperatures in each segment, guaranteeing process stability and reproducibility.

4. Current Monitoring Feedback System: Online monitoring of extrusion current to determine torque, providing feedback protection for the twin screws and extending their service life.

5. Dual Cooling System: Integrates water and air cooling to better ensure the stability of the heating temperature.

6. Modular Twin Screws: The twin screws adopt a multi-segment segmented design, integrating mixing, pressurizing, melting, extrusion, and cooling to ensure complete integration of the API and excipients.

7. Die Plate Selection: Interchangeable die plates with different shapes and apertures are available to adapt to various material properties.

8. Multi-stage Venting: Designed with multiple vent ports to effectively exhaust air and moisture from the molten material, reducing extrusion pressure and improving product quality.

9. Conveying and Shearing Device: Can be equipped with different shearing structures based on material characteristics to obtain uniform granules.

10. Compliance: GMP-compliant, easy to disassemble and clean. Featuring three-level password authorization, PLC automatic control, online data storage, and USB export capability.

11. Functional Expansion: Capable of Continuous Wet Granulation.

Specifications and main technical parameters: