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Dry granulation
Home / Granulation

Dry granulation

Product catalog

  • Granulation
  • Coating
  • Melt extrusion machine and pelletizing machine
  • Pulverization / Micronization / Mixing
  • Description
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Applications: Primarily used for granulating drugs whose stability significantly degrades upon exposure to water or other solvents. It achieves one-step granulation without any liquid binders, offering high efficiency, low energy consumption, and excellent product stability. By eliminating the drying stage, it prevents contamination between the drug and the environment while drastically reducing energy costs.

Operating Principle: Powder is pre-compressed and de-aerated by a conical screw before being fed into constant-pressure rollers to be compacted into sheets (ribbons). These sheets are then processed through a sizing system to become granules. The final particle size is determined by the screen mesh size and the speed of the sizing blades. The resulting dry granules can be used directly for tableting, granules for oral suspension, or capsule filling.

Key Features:

  1. Vertical Twin-Screw Feeding System: Provides forced, uniform feeding for materials with poor flowability, ensuring consistent compaction density and granule uniformity.

  2. Constant Pressure Roller System (Patent: ZL201620537059.9): Our proprietary lever-action constant pressure device uses a gas-liquid booster cylinder to drive the lever, controlling the vertical displacement of the upper roller. The stable pneumatic pressure prevents the uncontrollable pressure fluctuations often caused by rising oil temperatures in traditional hydraulic systems.

  3. Single-Motor Synchronous Drive System (Patent: ZL201620537491.8): A single motor drives the gear transmission to achieve counter-rotation of the twin rollers. This ensures absolute synchronization, effectively preventing “lamination” or uneven sheeting.

  4. Water Cooling System: Utilizes negative pressure water suction via a vacuum pump to facilitate water circulation, cooling the rollers and reducing ribbon temperature to maintain material stability.

  5. Two-Stage Sizing System: Stage 1 uses a Fitzmill structure to break large ribbons into flakes; Stage 2 uses a Comil structure with various grater-hole screens to optimize the yield of qualified granules.

  6. Customization: Options for vibratory or twin-screw feeders, various roller surface types, and constant torque systems based on customer requirements.

  7. GMP Compliance: Features three-level password authorization. All process parameters are PLC-controlled, with automatic online data storage and USB export capability.

Laboratory Model Specifications and Main Technical Parameters:

Model RDG60 RDG80 RDG120
Total Power (kW) 1 3 5
Capacity (kg/h) 0.1-1 1-10 5-30
Speed (rpm) Feeding 10-100 10-150
Roller 1-7 6-20
Primary Granulation None 50-300
Secondary Granulation None 50-500
Secondary Granulator Model — P100 P150
Roller Specification (mm) 60×12 80×25 120×35
Roller Pressure (KN) 0-15 0-70 0-120
Screen Specification (mm) 0.5, 0.6, 0.9, 1.2, 1.5, 2.0, 2.5, 3.0, 3.5 (Optional square holes)
Power Supply 220V/50Hz

1P 3W

380V/50Hz

3P 5W

Air Source Pressure (Mpa) > 0.5 > 0.5 > 0.5
Dimensions (mm) 800×750×700 1400×900×1600 1700×1200×1650
Machine Weight (kg) 200 500 800

Production Model Specifications and Main Technical Parameters:

Model RDG60 RDG80 RDG120
Total Power (kW) 1 3 5
Capacity (kg/h) 0.1-1 1-10 5-30
Speed (rpm) Feeding 10-100 10-150
Roller 1-7 6-20
Primary Granulation None 50-300
Secondary Granulation None 50-500
Secondary Granulator Model — P100 P150
Roller Specification (mm) 60×12 80×25 120×35
Roller Pressure (KN) 0-15 0-70 0-120
Screen Specification (mm) 0.5, 0.6, 0.9, 1.2, 1.5, 2.0, 2.5, 3.0, 3.5 (Optional square holes)
Power Supply 220V/50Hz

1P 3W

380V/50Hz

3P 5W

Air Source Pressure (Mpa) > 0.5 > 0.5 > 0.5
Dimensions (mm) 800×750×700 1400×900×1600 1700×1200×1650
Machine Weight (kg) 200 500 800

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Tin Nghi Dac Pharmaceutical Equipment Co., Ltd.

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